Review of boceprevir and telaprevir for the treatment of. Telaprevir brand name incivo is a new medication used to treat hepatitis c. It was approved in europe in september 2011 for treatment of adults with genotype 1 chronic hepatitis c in combination with pegylated interferon and ribavirin. Highlights of prescribing information coadministration of. The information in this table was obtained from package inserts for boceprevir and telaprevir february 2012. Center the spike within the circle on the stopper top. Victrelis must be administered in combination with peginterferon alfa and ribavirin. The apparent volume of distribution at steady state ranged from 43 to 90 l. The standard therapy of pegylated interferon and ribavirin is less effective than telaprevir in those with genotype 1. Apr 26, 2012 the information in this table was obtained from package inserts for boceprevir and telaprevir february 2012. Consult a pharmacist or the package insert for information about each. Severe rash like stevenjohnson syndrome or drug rash with eosinophilia and systemic symptoms are very rare. Telaprevir is used along with two other medications ribavirin copegus, rebetol and peginterferon alfa pegasys to treat chronic hepatitis c an ongoing viral infection that damages the liver in people who have not yet been treated for this condition or whose condition could not successfully be treated with ribavirin and peginterferon alfa alone. Thus, there is a significant pharmacokinetic interaction between telaprevir and ribavirin that results in very high.
Effects of boceprevir and telaprevir on the pharmacokinetics of dolutegravir. Open your powerpoint presentation on the page you want to insert the pdf within. Highlights of prescribing information 3 prs 16 weeks 16. Toposar is contraindicated in patients who have demonstrated a previous hypersensitivity to it. Telaprevir crosses into the breast milk and it is recommend for women to use two forms of birth control while on this medication. After one week, increase the dose to the recommended. Advate antihemophilic factor recombinant, plasmaalbuminfree method for intravenous use, lyophilized powder for reconstitution initial u. Telaprevir should be used with caution with warfarin because telaprevir can increase or decrease warfarin coumadin breakdown, increasing or decreasing the effect of warfarin. They should be swallowed whole with a glass of water. Used to treat pulmonary hypertension at high doses. Highlights of prescribing information these highlights do not include all the information needed to use incivek safely and effectively.
Click the image and it will be inserted into the slide. Highlights of prescribing information nss are frequent nss. Refer to the peginterferon alfa and ribavirin package inserts for instructions on dosing. Pharmacist information sheet important dispensing information for every patient, temodar must be dispensed in a separate vial or in its.
Cutaneous eruption due to telaprevir fulltext case reports in. These highlights do not include all the information needed to use temodar safely and effectively. This emedtv segment further explores telaprevirs mechanism of action and provides a link to more detailed information on this prescription drug. Telaprevir for previously untreated chronic hepatitis c virus infection article pdf available in new england journal of medicine 36425. Dispense enclosed patient package insert to each patient. In both treatmentnaive and treatmentexperienced patients, sustained virological response rates were achieved more often with boceprevir or telaprevir in combination with pegylated interferon and ribavirin compared with pegylated interferon and ribavirin alone. Drug class contraindicated with boc1 contraindicated with tvr2 alpha 1. Ribavirin fda prescribing information, side effects and uses. Open powerpoint and create a new presentation or open an existing ppt file. If so, share your ppt presentation slides online with.
By blocking the activity of certain enzymes, telaprevir can prevent the hepatitis c virus from multiplying. Begin at a dose of 1 mg once daily and adjust in increments of no more than 1 mgweek 2. The aim was to evaluate the effect of boceprevir and telaprevir on dolutegravir pharmacokinetics pk. How to insert a pdf into powerpoint online tech tips.
Faslodex fulvestrant injection 500 mg for health care. Effects of boceprevir and telaprevir on the pharmacokinetics. Consult a pharmacist or the package insert for information about each drugs safety during pregnancy and breastfeeding. Full prescribing information 1 indications and usage ingrezza is indicated for the treatment of adults with tardive dyskinesia see clinical studies 14. Highlights of prescribing information incivek tm initial u. Apokyn apomorphine hydrochloride injection, for subcutaneous use initial u.
Doselimiting bone marrow suppression is the most significant toxicity associated with etoposide therapy. Open the ppt and go on the slide that you want to insert a pdf into. However, as stated in the telaprevir package insert treatment. These highlights do not include all the information needed to use apokyn safely and effectively. This emedtv page takes a closer look at dosing guidelines, with details on why this medication is not used alone and helpful tips on taking telaprevir. Highlights of prescribing information these highlights do not include all the information needed to use valcyte safely and effectively. Youve just received a pdf from a client or coworker, and you need to add the content to your powerpoint presentation. When possible, interrupt therapy with brilinta for fivedays prior to surgery that has a major risk of bleeding. Telaprevir should be used with caution with warfarin because telaprevir can increase or decrease warfarin coumadin breakdown, increasing or. Do not crush, chew or break tablets before swallowing 2. Ribavirin should be given in combination with peginterferon alfa2a. Anemia mechanism of anemia thought to be result of bone marrow suppressive effect associated with telaprevir, not rbc hemolysis patients treated with telaprevir had a higher frequency of anemia, hemoglobin level incivek telaprevir, in combination with peginterferon alfa and ribavirin, is indicated for the treatment of genotype 1 chronic hepatitis c in adult patients with compensated liver disease, including cirrhosis, who are treatmentnaive or who have previously been treated with interferonbased treatment, including. Ribavirin for inhalation has a separate package insert, which should be consulted if ribavirin inhalation therapy is being considered. Excel for office 365 word for office 365 outlook for office 365 powerpoint for office 365 publisher for office 365 visio plan 2 word for the web visio professional 2019 visio standard 2019 visio professional 2016 visio standard 2016 visio professional 20 visio.
Incivek telaprevir, in combination with peginterferon alfa and ribavirin, is indicated for the treatment of genotype 1 chronic hepatitis c in adult patients with compensated liver disease, including cirrhosis, who are treatmentnaive or who have previously been treated with interferonbased treatment, including. When using an intravenous infusion pump, administer integrilin undiluted directly from the 100ml vial. Unless otherwise specified, the information in the following summaries applies to adults, not children. This emedtv segment further explores telaprevir s mechanism of action and provides a link to more detailed information on this prescription drug. Learn more about faslodex fulvestrant injection 500 mg, a treatment option for hr positive, her2 negative advanced breast cancer in postmenopausal women not previously treated with endocrine therapy. Limit initial dose to 15 mg once daily in patients with nyha class i or ii heart failure. Highlights of prescribing information these highlights. Anemia mechanism of anemia thought to be result of bone marrow suppressive effect associated with telaprevir, not rbc hemolysis patients treated with telaprevir had a higher frequency of anemia, hemoglobin level inc. Mavyret is indicated for the treatment of adult and pediatric patients 12 years and older or weighing at least 45 kg with hcv genotype 1 infection, who previously have been treated with a regimen containing an hcv ns5a inhibitor or an ns34a protease inhibitor, but not both. Package insert and patient information 10 ml of sterile water for injection using baxject ii pdf 187kb package insert and patient information 5 ml of sterile water for injection using. If there is inadequate glycemic control, the dose can be increased in 15 mg increments up to a maximum of 45 mg once daily. Valcytevalganciclovirtablets, valcytevalganciclovir hydrochloride fororal solution initial u.
Telaprevir is only indicated for use against hepatitis c genotype 1 viral infections and has not been proven to have an effect on or being safe when used for other genotypes of the virus. Highlights of prescribing information hypersensitivity to. For the treatment of hepatitis c with telaprevir, the standard dose is 1125 mg taken two times daily. Incivek telaprevir film coated tablets, for oral use initial u. Do not administer with highfat meals, because of increased exposure 2. Highlights of prescribing information for intravenous. Rna at weeks 4 and 12 of telaprevir combination treatment may benefit from an additional 36 weeks of peg. Insert pdf file content into a powerpoint presentation powerpoint. Current standards and new paradigms is the property of its rightful owner. Pdf telaprevir for previously untreated chronic hepatitis c. Consult the full prescribing information prior to use for potential drug interactions. Highlights of prescribing information these highlights do not include all the information needed to use advate safely and effectively.
Insert pdf content into your presentation either as a picture that shows on your slide, or as a document that you can open during your slide show. The pdf file should be the first option within the insert dialog window. Telaprevir mechanism of action hepatitis home page. Dec 29, 2011 however, as stated in the telaprevir package insert treatment. Temodar temozolomide capsules should not be opened or chewed. The dose of victrelis is 800 mg four 200mg capsules three times daily every 79 hours with food a meal or light snack see table 1. If you have any questions about telaprevir, please talk with the doctor, pharmacist, or other health care provider. To insert a pdf into powerpoint without losing quality, follow the steps below. Incivek telaprevir tablets, for oral use initial u. Warnings patients being treated with toposar must be frequently observed for myelosuppression both during and after therapy. If capsules are accidentally opened or damaged, precautions should be taken to avoid inhalation or contact with the skin or mucous membranes see how suppliedstorage and handling 16. The studies identified assessed boceprevir and telaprevir in genotype1 hepatitis c patients. Prsprior treatment experience with regimens containing interferon, pegylated interferon, ribavirin, andor sofosbuvir, but no prior treatment experience with an hcv ns34a pi or ns5a inhibitor.
Highlights of prescribing information valcytefor oral. Telaprevir can slow the breakdown of these medications and increase their levels in the body, leading to increased side effects and toxicity. Administer integrilinby volume according to patient weightsee table1. Jan 25, 2019 initiate actos at 15 mg or 30 mg once daily. Page 1 of 36 highlights of prescribing information these highlights do not include all the information needed to use perjeta safely and effectively. Follow the package insert for the management of rash. This medicine comes with an extra patient fact sheet called a medication guide. When possible, interrupt therapy with brilinta for fivedays prior to.
829 1042 1304 1449 760 590 47 1280 410 1545 1462 1270 1265 1040 949 680 619 938 690 34 1289 1505 1402 532 475 689 1149 1080 502 289 341 1248 376 699 1311 777 1497 704 381 514 1266 676